Claire le pichon5/16/2023 ![]() Much of my time is spent participating in discovery project teams at various stages, from HTS assay development to early clinical development, providing and interpreting data, gaining greater insights into target biology, through collaborations with research biologists, and into drug design and optimization. (2017) Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull. Sci Transl Med 9: Ghitani, Nima Barik, Arnab Szczot, Marcin et al. (2017) Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. In support of this goal I also spend some time developing and supporting data analysis workflows and tools for large-scale biology, including high-content analysis and compound selectivity and phenotypic profiling. Le Pichon, Claire E Meilandt, William J Dominguez, Sara et al. To achieve this we have to walk the line between reductionist mechanistic approaches and fuzzy systems-level phenotypic profiling. Le Pichon is an impressive and inspirational scientist, especially for aspiring female researchers. Our goal is to enable discovery of drug candidates with molecular mechanisms of action that have the best chance of translating to clinical benefit. PMID 22985112 DOI: 10.1021/Jm301020Q : 0.589: 2009: Le Pichon CE, Valley MT, Polymenidou M, Chesler AT, Sagdullaev BT, Aguzzi A, Firestein S. We have a strong emphasis on taking functionally meaningful cellular responses and phenotypes and converting them to high-throughput quantitative assays, as well as developing biochemical assays that provide the most critical information on compound potency, selectivity, and mechanisms of action. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. PDF Laboratory Review of Foodborne Disease. Ptisserie Xavier BRIGNON 856 billeder 155 anmeldelser. ![]() Calamo Fou De P 226 Tisserie N29 Mai Juin 2018. 60 meilleures images du tableau Ptisserie en 2020. I have the privilege of leading a group of Scientists and RAs who all serve critical roles in contributing to and supporting small molecule drug discovery projects. Fou De Pâtisserie By Claire Pichon Fou De Pâtisserie By Claire Pichon Les 47 meilleures images de Glacage miroir chocolat. ![]()
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